Abstract

Enantioselective Organocatalysis in Flow Mode

Oliver Kappe, Professor, Karl Franzens University of Graz

Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated to benefit considerably from the merits of continuous processing and microreactor technology. Over the past few years, continuous flow enantioselective organocatalysis has grown into a mature field and has found diverse applications in asymmetric synthesis of pharmaceutically active substances. In this lecture flow chemistry-based approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of immobilized metal-free organocatalysis to introduce asymmetry in continuously operated systems will be presented. Single-step processes, interrupted multistep flow syntheses and uninterrupted one-flow syntheses from our group will be discussed.