Abstract

Anti-Aging MSC-EVs

Sai Kiang Lim, Research Director, A*STAR Institute of Medical Biology

Aging is believed to be, in part, a result of the decline in functional adult stem cells that are crucial for maintaining tissue homeostasis. We had previously postulated that MSC EVs could help preserve the balance of cell numbers by activating survival signaling pathways. Indeed, our research showed that EVs derived from MSCs effectively reduced senescence both in cell cultures and in live organisms, leading to an improvement in the natural lifespan of aging mice.