Abstract

Extracellular Vesicles-mediated Organ Crosstalk in Systemic Inflammatory Disorders

Nazli Khodayari, Assistant Professor, Medicine Department, University of Florida

Liver has a key role in the modulation of systemic inflammatory responses. It is evidenced that normal liver function exerts lung protection and is necessary for recovery from lung damage. Lung–liver axis is critical for integrating systemic responses and disbalance in this communication can be an important factor in the damage to both organs. EV have been shown to regulate pathophysiological events via their intercellular and inter-tissue transfer of their cargo. In chronic lung inflammatory diseases, changes in the number and content of EV have been reported during exacerbation of the disease. The liver is exposed to EV released by intrahepatic and various extrahepatic cells and organs such as lung through blood circulation. Circulating pro-inflammatory EV can promote liver fibrosis by activating liver immune cells. Here, we investigate the contribution of extrahepatic inflammation in the progression of alpha-1 antitrypsin deficiency-mediated liver disease, by focusing on lung derived proinflammatory EV.