Abstract

Micro Innovations Defining the New Frontiers of Liquid Biopsy

Sunitha Nagrath, Professor of Chemical Engineering and Biomedical Engineering, University of Michigan-Ann Arbor

Microfluidic technologies were always at the forefront of innovations in liquid biopsies. There were several corner stone microfluidic technologies that enabled sensitive and yet specific identification of blood-based biomarkers. The confluence of technology advancement and rapid developments in molecular characterization techniques pushed the boundaries of liquid biopsies thus enhancing the clinical utility of blood biopsies. Several such key enabling technologies will be presented. How isolation of circulating tumor cells using novel microfluidic technologies can enable precision diagnostics will be demonstrated with the example clinical case studies.