Abstract

Generation and Use of Reactive Species Under Continuous Flow Conditions

Julio Cezar Pastre, Associate Professor, University of Campinas – UNICAMP

A distinct advantage when performing transformations in continuous flow is the ability to handle reactive or short-lived intermediates and safely determine the destiny of these species without isolation or exposure to these hazardous materials. This ability to control reactive intermediates affords greater flexibility in processing, by defining product outcomes or aiding scale-up. In this talk, I will present some contributions to the generation of reactive intermediates such as acylketenes, unstabilised diazo compounds, radicals and further exploitation of their chemistry to the synthesis of key building blocks.