Abstract

Overcoming Selectivity and Scalability Challenges via Continuous Photochemistry

Marcus Baumann, Assistant Professor, School of Chemistry, University College Dublin

In this talk we will highlight recent work from our group showcasing the use of flow photochemistry for reactions that cannot be performed effectively and/or selectively in batch mode. This will include heterogeneous (solid/liquid) photoreactions using a new photo-CSTR module towards unstable pyrazolines, the aerobic photo-oxidation of benzylic substrates using compressed air as well as a series of intricate azaheterocycles that exploit chromoselective transformations of vinyl azides and azirines. Reaction telescoping as well as inline purification strategies will be highlighted along with gram-scale preparations towards selected targets. Overall, this approach offers an improved and potentially greener route towards a variety of valuable chemical building blocks based on exploiting modern flow approaches.