Abstract

Microfluidics in Liquid Biopsy and Integration in Functional Studies

Lorena Dieguez, Staff Researcher, INL

Microfluidics has demonstrated numerous advantages for isolation and characterization of liquid biopsy biomarkers in oncology, with increased sensitivity and throughput, enabling their implementation in clinical routine. Microfluidics is also very relevant to build biomimetic and dynamic 3D models to better understand the process of metastasis. In this talk, we present our most recent work for the development of holistic liquid biopsy assays, by integrating microfluidic extraction of CTCs, cfDNA, and EVs; and application of viable CTCs in functional models for the study of metastasis.