Abstract

Human Telomerized Cell Cultures to Establish Relevant and Standardizable Pre-Clinical in vitro Test Systems

Regina Grillari, CTO And Co-Founder, Evercyte GmbH

Organ-on-a-chip models mimic physiological conditions to study organ functions in vitro, with their effectiveness depending on cell source choice. Primary cells face challenges like donor variability and limited lifespan, while immortalized cell lines offer indefinite growth and stable characteristics, ideal for long-term studies. Evercyte's immortalized cell lines, resembling primary cells in function and morphology, have been integrated with microfluidic technology to create single and multi-organ chips. This integration replicates critical in vivo elements, providing a robust platform for preclinical research on cellular responses, toxicity, and biomarkers.