Abstract

Tumor Microenvironment 3D Cell Models to Address Therapeutic Response

Giacomo Domenici, Associate Scientist, Instituto de Biologia Experimental e Tecnológica (iBET)

The presentation will focus on the following topics:

• Representation of the Tumor microenvironment (TME) is critical to study response to advanced therapeutics.
• Different strategies to represent the TME, developed in the Lab will be presented, based on 3D cell culture models, namely:
• Reconstruction modeling strategies, involving cancer cell line derived spheroids and non-malignant TME cellular components co-cultures (e.g., fibroblasts, macrophages).
• Preservation modeling approaches employing patient-derived tumor tissue for translational and clinical research.