Abstract

Microphysiological System for Disease Modeling and Drug Testing

Jessie Jeon, Associate Professor, KAIST

3D in vitro microphysiological systems are developed for mimicking different disease models and to be used as drug screening assays. I will describe developed systems for investigating human cancer microenvironment and its usage in anti-cancer drug delivery. The developed system enables recreation of different aspects of cancer microenvironment with vasculature and either organ-specific cells or immune cells in addition to cancer cells. The advantages of using microfluidic systems as disease model and drug screening assay include requiring only small sample volume, minimized manual repetition and relatively fast turnout time. Overall, the microfluidic model developed can reproduce different pathological microenvironment, and can give the insights on drug efficacies for particular microenvironments.