Abstract

Methylation-based ddPCR for the Follow-Up of Patients with Cancers

Valérie Taly, CNRS Research Director, Group Leader and Professor, Université Paris Cité

Technological advances have been key to the great development of liquid biopsies that we have witness these last years. In particular droplet-based digital PCR, by its accuracy and high sensitivity has greatly contributed to our ability to detect and quantify cancer circulating biomarkers such as circulating tumor DNA.  In this presentation, we a specific focus will be made on the application of droplet-based digital PCR for the detection of blood-based methylation biomarkers (liquid biopsy). The results of several prospective clinical studies will be presented highlighting great potential of this technology for the follow-up of both advanced and localized cancers.