Abstract

Effort of Japan MPS-Projects for the OECD Test-Guideline Proposal of Gut-Liver MPS as the Alternative of Toxicokinetics Test

Seiichi Ishida, Professor, Sojo University

OECD Guidelines for the Testing of Chemicals (OECD TG) are a set of internationally accepted specifications for the testing of chemicals. Most of them were originally developed as animal tests, although the alternatives are awaited as widespread concerns of animal welfare. One of such case is the OECD TG417 toxicokinetic. Current OECD TG417 is a test guideline that describes studies that provide information on mass balance, absorption in vivo, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters based on animal experiment. We are attempting to develop the alternatives to this TG in AMED-MPS RS* project. I’ll present its current progress. I would like to introduce other Japanese initiatives including AMED-MPS2 project and Japan MPS Initiative.