Abstract

Scaling Mechanochemistry via Continuous Bead Milling Technology

Oliver Kappe, Professor, Karl Franzens University of Graz

Mechanochemistry offers significant potential to improve the efficiency, sustainability, and cost-effectiveness of pharmaceutical manufacturing. However, many mechanochemical approaches remain at relatively low technology readiness levels and lack the chemical intensity required for industrial implementation. In this lecture we examine a technology referred to as bead milling as promising method to scale mechanochemistry from lab to production scale. In addition to presenting several recent literature examples, a recent case study from our labs will be highlighted where an amidation reaction was scaled from gram scale using ball milling equipment to multikilogram scale employing commercially available bead mills of different sizes/volumes.