Abstract

Harnessing Microfluidics & Flow Chemistry: A Precision Toolset from Synthesis to Nanomaterials

Dong-Pyo Kim, Yonsan Chaired Professor, Center for Intelligent Microprocess of Pharmaceutical Synthesis, POSTECH

The paradigm of chemical synthesis is shifting from traditional batch-based methods to precision-controlled flow systems. This seminar presents recent breakthroughs in Microfluidics and Flow Chemistry and their transformative impact on the production of micro-, nano-particles, and nanomaterials. I will first discuss our expertise in ultrafast reaction control and rapid synthesis of nanomaterials through precisely controlled processes. Recently, we have focused on AI-based autonomous discovery platforms, where machine learning and microfluidics work in tandem. This system enables precise control of parameters—such as injection rate, concentration, temperature, and reagent mixing ratios—to autonomously design the optimal structure and function of target materials. Furthermore, the sealed microflow reactors enable the conduct of novel chemistry at harsh conditions. In the final part, I will share perspectives on how these AI-driven microfluidic tools can support the precise manufacturing of next-generation drug delivery systems for advanced theranostics.