Abstract

Continuous Flow Synthesis Towards Local API Manufacturing

Paul Watts, Distinguished Professor and Research Chair, Nelson Mandela University

Africa has a variety of formulation companies; however the active pharmaceutical ingredients (APIs) are generally imported, making medications unaffordable to many patients in developing countries.

When micro reactor technology and flow chemistry was introduced it was seen as a research and development tool, however it is now being used to produce large quantities of product, especially in Asia.

To this effect, we are working on developing local drug manufacturing capacity in Africa using continuous flow technology, with the goal of lowering the cost of drugs, improving drug accessibility and ultimately improving Africa’s health. A selection of cases studies will be presented.