Abstract

Automated Continuous-Flow Synthesis of ADCs and Oligonucleotide Monomers

Fang Zhao, Professor School of Pharmacy, East China Normal University

Automated synthetic systems for both antibody–drug conjugates (ADCs) and oligonucleotide monomers were developed, enabling two-step fully continuous-flow synthesis in both cases. The reaction time has been dramatically reduced from 8–12 hours to less than 20 minutes. For ADC synthesis, the reaction temperature has been raised from low temperature to room temperature. For oligonucleotide monomer synthesis, no additional catalyst or base is required. These advances represent breakthroughs in terms of space efficiency, time savings, and environmental friendliness.