Abstract

Whole Genome Sequencing Analysis of Liver Cancer and Personalized Cancer Medicine

Hidewaki Nakagawa, Laboratory Head, RIKEN Center For Integrated Medical Sciences

Liver cancer is one of the most common and deadly cancers worldwide, especially in Asia, and has no effective treatment, yet its molecular mechanism remains largely unknown. Now whole genome sequencing analysis by next-generation sequencing and IT technologies for liver cancers is demonstrating comprehensive landscape of various phenotypes of liver cancers with multiple etiological backgrounds (HBV-infected, HCV-infected and non-virus, HCC and biliary phenotype) for point mutations, short indels, CNVs, SVs, and virus integrations. Comparison among whole genomic pictures of heterogeneous liver cancers can clarify the underlying liver carcinogenesis and achieve molecular sub-classification of liver cancer, which facilitates its genomic biomarkers discovery and personalized cancer medicine.