Abstract

A Novel Approach to Overcome Oncogenic Addiction via 3D Model Systems

Hakim Djaballah, CEO, Institute Pasteur - Korea

Classical drug discovery approaches for oncology have relied heavily on killing cancer cells; they have worked very well in some cases but not as good as predicted in others with many failures reported the clinic. We have taken an opportunistic approach looking for small molecules which would selectively revert the addictive state of the cancer cell yielding a vulnerable phenotype. I will describe the approach and discuss our findings thus far with the ultimate goal of progression to the clinic.