Abstract

Why a Dendritic Approach to Nanomedicines?

Delphine Felder-Flesch, Researcher, Institut de Physique et Chimie des Materiaux de Strasbourg

Our main objective is to create dendrimers and dendronized hybrids at the nanoscale combining targeted detection properties by multi-modal medical imaging with therapeutic properties, supplying an image-guided therapy. The small size of the dendritic objects and the dendronized nanoparticles is mandatory as it allows envisaging a crossing of the capillary barrier, a urinary elimination and a favourable biodistribution: in vivo studies performed with dendritic 111In-radiopharmaceuticals on melanoma cancer and for the characterization of the sentinel lymph node, but also pre-clinical studies performed with dendronized iron oxides of various sizes and shapes will be discussed.