Abstract

Integrated Silicon Biophotonic Devices for Point-of-Care Diagnostic Applications

Mi Kyoung Park, Head, A*STAR (Agency For Science Technology And Research)

Recently, silicon waveguide based biosensors have gained significant attention because of their high sensitivity, extremely small footprint and the scalability of the device fabrication. The silicon biophotonic devices provide a promising means for the label-free detection of target molecules and for the real-time monitoring of solutions that occur near the device surface. We describe our recent developments in integrated Lab-on-a-Chip (LOC) systems based on silicon biophotonic sensors for point-of-care applications. The system typically comprises of silicon microfluidic device for sample processing and novel silicon biophotonic sensors for label-free multiplexed detection of target molecules. We also present recent results demonstrating highly sensitive and rapid Mycobacterium tuberculosis (MTB) detection with silicon microring device using an isothermal solid-phase amplification/detection (ISAD) technique. These demonstrations establish a pathway to rapid, cost-effective multiparameter analysis from real-world patient samples; a development that will enable disease diagnostics at point-of-care and personalized medicine.