Abstract

Advanced Biomanufacturing of Functional Tissues

Andrew Lee, Director of 3D Bioprinting, FluidForm Inc.

Significant efforts to engineer tissues with controlled composition and architecture has resulted in the development of a wide range of specialized bioprinting processes that have produced impressive results. The challenge for implementing these bioprinting processes is in finding effective and efficient paths toward fulfilling new and wide-ranging applications as well as in developing robust, clinically-relevant solutions. Here, we introduce Freeform Reversible Embedding of Suspended Hydrogels (FRESH) as a versatile 3D bioprinting platform that can serve as a tissue fabrication sandbox for researchers and clinicians. We will discuss the design and fabrication of functional components of the heart to demonstrate the ability of FRESH to assemble soft native materials in complex geometries. We will then extend these capabilities toward discussing the potential applications of FRESH as a core technology in tissue engineering and beyond.