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SELECTBIO Conferences 3D-Culture, Organoids & Tox Screening Europe 2019


Human Induced Pluripotent Stem (iPS) Cells in Glaucoma Modeling with an Automated Platform and 3D Retinal Organoids

Maciej Daniszewski, PhD Student, University of Melbourne

Glaucoma is a disease characterized by slow degeneration of retinal ganglion cells (RGCs) what leads to irreversible vision loss and may ultimately result in blindness. It is estimated that approximately 80 million people will be affected by the disease in 2020, and with aging populations, this number will only continue to grow, thus generating a significant financial burden on the healthcare system.

Nevertheless, its exact molecular mechanism remains elusive. The use of human pluripotent stem cells (hPSCs) and three-dimensional (3D) organoids may bring a long-awaited breakthrough. Organoids mimic the organization and physiology of the tissue and thus recapitulate the disease phenotype more closely than 2D models. Organoid-derived RGCs may help to extend our understanding of mechanisms that confer risk of developing the disease, but also those that govern its progression.

Add to Calendar ▼2019-06-13 00:00:002019-06-14 00:00:00Europe/London3D-Culture, Organoids and Tox Screening Europe 20193D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The