Diagnosis of Ischemic Heart Disease Using Plasma Extracellular Vesicles
Dominique PV de Kleijn, Professor Experimental Vascular Surgery; Professor Netherlands Heart Institute, University Medical Center Utrecht
Cardiovascular Disease (CVD) is with the cardiovascular events of
Ischemic Heart Disease and Stroke, the number 1 and 2 cause of death in
the world and expect to increase especially in Asia. Ischemic heart
disease (IHD) comprises 3 entities: stable coronary artery disease
(SCAD), unstable angina (UA) and myocardial infarction (MI). Because IHD
is associated with an increased risk of adverse clinical events such as
heart failure and death, early recognition of IHD is of utmost
importance. However, to diagnosis IHD is challenging, as many patients
present with atypical symptoms. It is known that women have a different
symptom sensation than men. Troponins are the main diagnostic tool for
detection of MI. Blood biomarkers for SCAD (typically causing stable
angina) and UA, however, are not available. These diagnoses frequently
require hospital visits/admissions for time-consuming and costly
(non)invasive tests. We show that the plasma extracellular vesicle
content can be used as an accurate source for early diagnosis of SCAD
and UA.
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