Abstract

Application of Artificial Intelligence and Semiconductor Technologies in Liquid Biopsy

Chung- Er Huang, Assistant Professor, National Chiao Tung University; Managing Director, CytoAurora Biotechnologies, Inc.

The demand for basic research and commercial applications of liquid biopsy has increased along with the need for reliable automation to promote the market growth. In this presentation, we will introduce a novel system (“Cell Reveal”) for rare cells captured. The novel system in capturing rare cells (CTC/CFC) has been robustly developed based on an advanced technology which integrates semiconductor manufacturing technology, biotechnology, automation, and artificial intelligence.  The system (“Cell Reveal”) consists of cell-capture, cell-analysis, enumeration, and cell separation.  The capture of rare cells is performed by a combination of a bio-chip and microfluidics as the cells flow through the surface of the biochip.  The high capture rate of the bio-chip is achieved by a similar dimensional nano-structure in a high-density arrangement. Enumeration of rare cells can be accomplished by the Cell Analysis Tool, which also provides molecular analysis and genetic makeup of the target cells as well as their locations on the chip. The intact cells are subjected to separation, resulting in individual target cells collected for subsequent single Whole Genome Amplification (WGA) and WGS.  This novel nano-system greatly improves and accelerates patients' diagnostics and therapeutics.