Abstract

Silicon Chip Nanofluidics for Extracellular Vesicle Enrichment

Benjamin Wunsch, Surface Chemist, IBM Corporation

Silicon lithography provides a high resolution and scalable route to fabricating nanofluidic structures on a chip. We describe a silicon chip based on the nanoscale deterministic lateral displacement (nanoDLD), for enriching extracellular vesicles from biological fluids based on size. We report on our pilot efforts to use high- throughput extraction of EVs from urine and serum to aid in the identification of cancer-specific biomarkers.