Choosing the Right Cell-Based Assays for Drug Discovery
Suresh Juluri, Assistant Director, Jubilant Biosys Ltd.
Drug discovery
starts with the selection of validated targets followed by setting up of
screening assays for evaluating compounds with the right potency, selectivity
and drug-like properties. Central to this screening cascade is the choice
of the appropriate cellular assays in the flow scheme. This talk will cover the
broad target classes and appropriate cellular assays for them, the value of
phenotypic screening and the importance of establishing target engagement in
primary cell types. The advantages and caveats of cellular assays will
also be discussed.
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