Abstract

Bioengineering the Inflammatory and Degradative Cross Talk in Arthritic Diseases with Patient-derived Chondro-synovial Joint-on-a-chip Systems

Mario Rothbauer, Principle Investigator, Medical University of Vienna

Arthritic musculoskeletal diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) concern great parts of our global population. The communication of multiple tissues during onset and progression is characterized by inflammatory as well as degradative molecular processes that can in strong pathologies lead to join replacement surgery. The inflammatory and degradative interaction of joint tissues plays a vital role to aggravate tissue degradation in both arthritic diseases. The first half of the talk will cover the development of a chondro-synovial joint-on-a-chip system using patient-derived organoids and discuss how to develop an animal- and animal-product-free system with regards to serum supplements and biomatrices. The second half will outline the advances and progress made in modelling an authentic patient tissue-like osteoarthritis phenotype at architectural and molecular level using chondro-synovial joint-on-a-chip systems.