Exosome-Mediated Functional Delivery of Integrins Promotes Cancer Progression
Lucia R. Languino, Professor of Cancer Biology, Thomas Jefferson University
Our investigations focus on exosome-mediated transfer of integrin
surface receptors among subsets of cancer cells, and among cancer cells
and the surrounding microenvironment.
Our recent studies
demonstrate that exosomes from cancer cells contribute to horizontal
propagation of integrin-associated invasive phenotypes in a paracrine
fashion.
The presentation will cover the role of exosomal
integrins in cancer progression, and will discuss their potential use as
clinical biomarkers for non-invasive diagnosis and/or as therapeutic
targets in cancer.
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