Abstract

Extracellular Vesicles-Enabled Liquid Biopsy for Cancer Diagnosis, Prognosis, and Treatment

Yong Zeng, Associate Professor, Department of Chemistry, University of Florida

My research is primarily focused on the development of innovative liquid biopsy-based tests based on extracellular vesicles (EVs) and micro/nanobiosensing technologies for cancer diagnosis, prognosis, and treatment. Herein, we will discuss the nanoengineered systems and bioassays for efficient immunoisolation of circulating EVs and ultrasensitive profiling of EV biomarkers, including proteins and miRNAs.  Adaptation of our new technologies to clinical assessment of EV-based liquid biopsy for non-invasive detection, subtyping, and treatment monitoring of cancer will be demonstrated.