Abstract

Leveraging the Genome-Wide Cell-Free DNA Fragmentation in Patients With Cancer

Florent Mouliere, Assistant Professor, Cancer Center Amsterdam, VUMC Amsterdam

Liquid biopsies, and circulating tumor DNA (ctDNA) in particular, are used to non-invasively detect the presence of cancer cells. ctDNA is commonly detected though the presence of genetic alterations in its sequence. Since the majority of ctDNA in circulation is non-mutated, leveraging this untapped resource of tumor information makes sense for improving cancer detection, notably in early stage and brain cancers. Here I will show how the genome-wide fragmentation of cell-free DNA could be leveraged to enhance the detection of ctDNA.