Abstract

Process Analysis Utilizing Small Footprint Capillary Flow based NMR Spectroscopy

John Frost, Chemist, Thermo Fisher Scientific

Since the introduction of a new generation of small footprint, low cost NMR spectrometers in 2011 the market has exploded with offerings. The leader of this new class of NMR, the picoSpin®, has departed from the traditional 5 mm NMR tube, opting instead to utilize capillary based flow cell.  The capillary based flow cell and industrial design of this instrument has made it particularly interesting for integrating into the process analysis environment. We present the results of several systems utilizing readily available instruments and off the shelf components. A detailed discussion of the experimental setup, results and potential applications in the area of process analysis will be discussed.