Abstract

Development of Continuous Flow Chemistry Using Online PAT

Matt Bio, President/CEO , Snapdragon Chemistry

Continuous manufacturing technology, or flow chemistry, provides a potentially highly controlled and data rich environment for the development of robust manufacturing routes to complex molecules. Further, the technology can be leveraged to deliver low cost manufacturing plants and significantly simplified tech transfer. Realizing the benefits from continuous manufacturing technologies requires chemical, analytical and engineering expertise. The development of appropriate scale-down models for continuous manufacturing further complicates the efficient development of continuous manufacturing processes. The utility of the application of various process analytical technologies to the lab scale design and developing continuous processes for the pharmaceutical and fine chemical industry will be discussed. Case studies highlighting solutions and challenges of developing flow chemistry processes will be presented.