Abstract

Photoredox Catalytic Reactions in Continuous Flow Reactors

Maurizio Benaglia, Full Professor of Organic Chemistry, Università degli Studi di Milano

In the last few years, the use of continuous-flow systems has been widely exploited in the synthesis of chiral APIs (active pharmaceutical ingredients). Furthermore, the combination of organocatalysis and photochemistry may give a straightforward access to molecules which would otherwise be difficult to attain. Organocatalytic in flow reactions in (micro)-mesoreactors and in CSTRs (continuous stirred tank reactors) will be presented. A visible-light catalyzed cyclization of bis(enones) to afford enantiomerically enriched cyclopentane rings, a metallaphotoredox strategy for the synthesis of tryptamines and the use of packed-bed reactors in light-driven reactions will be discussed.