Abstract

Overcoming Antigen-Mediated Antibody Clearance

Tristan Vaughan, Vice President R&D, Antibody Discovery and Protein Engineering, MedImmune Ltd

An antigen can act as a “sink” for antibody clearance if the antibody binds to an antigen which is rapidly eliminated. High levels of antibody clearance can impede and often halt the development of a novel therapeutic due to an impossibly large dose that would be required to overcome the sink for the drug to bring any patient benefit.  Here, an antibody engineering solution to rapid clearance will be described and a case study presented.