Abstract

The Theranostic Potential of Membrane Hsp70 in Cancer: An Autologous Natural Killer (NK) Cell-based Therapeutic and Companion Diagnostic for Treating Tumours Expressing Membrane Hsp70

Graham Pockley, • Director and Professor, John van Geest Cancer Research Centre, Nottingham Trent University

A cell surface bound form of the 70 kDa heat shock (stress) protein Hsp70 is selectively, and widely expressed on the plasma membranes of many tumour entities. This presentation will summarise the current status of an NK cell-based therapeutic for the treatment of such tumours, the impact of checkpoint inhibition thereupon and the development of a Companion Diagnostic to identify patients bearing membrane Hsp70-expressing tumours.