Abstract

Scalable Wafer Level Production of Consumables for Life Science and Diagnostics Applications Made of Non-CMOS Compatible Materials on Glass. Challenges and Opportunities by Addressing Manufacturing and Standardization in a Foundry Concept

Alexios Tzannis, Business Development Manager, IMT Masken und Teilungen AG

Microfluidics, or lab-on-a-chip technology, is a powerful tool positioned in the intersection of biotechnology, automation, and functional integration. Microfluidic devices can shuttle picoliter, and smaller, volumes of fluids into functional regions, enabling powerful in vitro diagnostics (IVD) harnessing everything from digital biology, to next generation sequencing, organs-on-a-chip, high-throughput cell-based assays, or high-density multifunctional chips for drug discovery and bioanalysis, while shrinking sample and reagent volumes. The integration of surface functionalization as well as electronical, optical elements and valves provides a comprehensive biosensor made of a single substandard device. Moreover, hybrid integration of diverse materials such as polymers, silicon with glass can provide novel multilayer hybrid microfluidic devices. The overall complexity is addressed by transferring MEMS standardization protocols, methodologies and equipment available in the MEMS into the field of microfluidics. In this presentation, we discuss the challenges and solutions of implementing WLP processes for LOAC products.