Abstract

Cartridge-Ready Isolation and Concentration of Extracellular Vesicles

Richard Spero, CEO, Redbud Labs

Despite decades of innovation, there is no accepted standard for isolation of circulating biomarkers in microfluidic systems. This creates a problem for developers of new biomarker assays and liquid biopsy tests. Traditional sample prep methods such as ultracentrifugation, affinity sorting with magnetic beads, or micro-filtration are acceptable for use in a discovery environment. However, these methods do not translate effectively to microfluidic cartridges, so promising assays must be completely re-implemented when moving from the bench to an integrated system. We present our work on a high-performance sample prep method for circulating biomarkers that translates easily from the bench to a microfluidic cartridge.