Abstract

Joint-on-a-Chip as Alternative to Animal Models in Arthritis Research

Mario Rothbauer, Researcher, Vienna University of Technology

With a prevalence of about 1%, rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, characterized by progressive, intermittent inflammation leading to joint destruction and are among the most frequently diagnosed diseases in aged patients. The talk will cover the development of multiplexed organ-on-a-chips as next-gen in vitro models as disease model resembling onset and progression of inflammatory arthritis. Also, a teasing outlook on its application potential for replacement of animal models and future drug screening efforts will be discussed.