Abstract

Polydendrons: A New Nanoparticle Platform with Nanomedicine Opportunities

Steve Rannard, Group Leader & Vice Chair, University of Liverpool

The formation of polymeric nanoparticles that are able to permeate gut monolayers, and deliver nanoparticles into the bloodstream, is a challenge to nanomedicine but allows the benefits of circulating nanoparticles without the need for injection. We have developed a new polymer architecture – termed hyperbranched polydendrons – that mimic dendrimers but provide considerable benefits at expected reduced costs.  Through combinations of branched vinyl polymerisation, linear-dendritic hybrid concepts and controlled polymerisation, complex polymer architectures that nanoprecipitate to form uniform nanoparticles have been generated. Encapsulation is possible and preliminary data has shown a lack of cytotoxicity with, but significant permeation through, gut epithelium monolayers. Our initial data and synthesis strategy is presented with options outlined for future development.