Abstract

Biomembrane-on-a-chip

Yan Yan Shery Huang, Lecturer, University of Cambridge

A microvessel in vitro model, based on an extracellular matrix (ECM) integrated microfluidic chip, is presented for straightforward injections of collagen gel and cells (HUVECs) inside the chip. The confined channel size results in a rounded vessel (~100 µm in diameter), instead of a rectangular vessel. The convenient device setup facilitate live cell image acquisition, and statistical analysis of the 3-dimensional cell-microenvironment interaction. Based on this device, we visualise the cancer extravasation dynamics in regional microenvironments, and is currently building a model towards brain tumour on a chip.