Abstract

Towards Human on a Chip

Danny van Noort, , Linköping University

In this presentation I will introduce our established 3D cell culture chip (or OoC), showing its performance compared to 2D cell cultures, using primary rat liver cells and C3A cell line. From there, an 8-channel human liver IC50 chip will be presented, showing a good drug toxicity correlation to animal models. This means this chip is the first step towards predictive assays. Following, I will show, with our endocrine system on a chip, the effect of L-cells on the insulin production in beta-cells. This is a 2-channel connected system. By changing the concentration of glucose, there will be a change in the dynamics of insulin production. Finally, a human-on-a-chip, represented by a 4-channel device with lung, liver, kidney and fat cells, will be presented. Local release of growth factors and a base medium ensure for highly functional cell cultures.