Abstract

Construction of Organ-on-a-Chip Models For Pathological/Pharmacological Research

Shengli Mi, Professor, Tsinghua University-Shenzhen

Organ-on-chips refer to the cell culture devices based on microfluidic technology to simulate the physiological functions and behaviors of tissues and organs through arranging living cells in a micrometer-sized chamber and the continuous supply of cell culture media. Organ-on-chips haves two main application directions: one is to study physiological or pathological mechanisms, and the other is to perform drug research and development based on the functions of organs. Here we mainly introduce our work from three aspects: the construction of a liver model based on a microfluidic chip, the microfluidic devices for tumor migration research, and the construction of a multi-organ system for liver metabolism anticancer drug testing.