Abstract

Digital Resolution Proteomic and Genomic Diagnostics using Plasmonic-Photonic Hybrid Resonators

Brian Cunningham, Donald Biggar Willett Professor in Engineering, University of Illinois at Urbana-Champaign

The strong electromagnetic coupling between plasmonic nanoparticles and photonic crystal surfaces is used as the basis for an ultrasensitive detection platform called “Activate Capture + Digital Counting” (AC+DC) that offers single step, isothermal, rapid, 100 aM, selective detection of protein and nucleic acid target molecules without wash steps or enzymatic amplification.  The talk will describe the operating principles of the AC+DC approach, provide representative examples for miRNA and protein biomarker detection, and describe applications for the technology for cancer genomic diagnostics.