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SELECTBIO Conferences Point-of-Care Diagnostics, Global Health & Biosensors 2019

Abstract



Development of an HIV-1 Viral Load POC Test

Jonathan D Posner, Professor of Mechanical Engineering & Chemical Engineering, University of Washington

The HIV/AIDS epidemic continues to be a major global health challenge, and accurate, affordable HIV-1 viral load testing is increasingly needed at the point-of-care (POC). Nucleic acid amplification tests (NAATs) provide high diagnostic accuracy of infectious diseases, yet most systems are restricted to central laboratories due to assay and instrumentation complexity. Here we describe a paper membrane based NAAT with integrated sample preparation and amplification using isotachophoresis and recombinase polymerase amplification.  This approach has the potential to reduce the cost and complexity of point-of-care (POC) NAATs. We demonstrate the detection of HIV-1 nucleic acids in whole blood. Preliminary data demonstrate linearity at low copy number which may provide valuable quantitative data on the HIV viral load of a patient.


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Add to Calendar ▼2019-10-07 00:00:002019-10-09 00:00:00Europe/LondonPoint-of-Care Diagnostics, Global Health and Biosensors 2019Point-of-Care Diagnostics, Global Health and Biosensors 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com