Abstract

Exosome-based Cell Free Therapy

Takahiro Ochiya, Professor, Tokyo Medical University

Extracellular vesicles (EVs) play important roles in intercellular communications via their content molecules, and mimic, at least in part, the roles that are played by their originating cells. Consistent with this notion, an increasing number of reports have suggested that EVs including exosomes derived from mesenchymal stem cells (MSCs), which are therapeutically beneficial to a wide range of diseases, can serve as drugs to treat multiple diseases. EVs contain a variety of molecules, including proteins, microRNAs, and mRNAs, and are associated with biological processes in a content molecule-dependent manner. In this presentation, it will be reviewed the latest reports regarding the therapeutic potential of MSC-EVs by focusing on the underlying molecular mechanisms of their effects. Specifically, it will be notified the effects of MSC-EVs in terms of their content molecules and of the tissue recovery processes endowed by these molecules for exosome-based cell-free therapy.