Abstract

Screening Natural Product Extracts in Cell-free and Cell-based Assays Systems

Barry O'Keefe, Group Leader, National Institutes of Health

Natural products are the source of >30% of all approved drugs world-wide and >50% of anti-cancer drugs approved over the last 10 years. Despite this overall success rate, natural product extract screening is absent from many commercial drug-discovery screening programs. This talk will examine the adaptations necessary in modern HTS programs to enable the screening of natural product extracts at the National Cancer Institute. Examples from both cell-free and cell-based screens will be used to illustrate how natural product extracts can be successfully utilized.