Abstract

Modeling Effects of Microgravity on Kidney Function with a Human “Kidney Chip”

Edward Kelly, Associate Professor, University of Washington

We have developed a 3D microphysiological system (MPS) model of the human kidney that recapitulates the functions of the proximal tubule as well as responses to toxic insults. To understand the effects of microgravity on kidney function, we sent our MPS to the ISS. Functional readouts included production of urinary biomarkers of acute kidney injury and metabolism of vitamin D after extended (>7 days) culture in microgravity.