Biointelligent Manufacturing and Systems Supported by 3D Bioprinting
William Whitford, Strategic Solutions Leader, GE Healthcare Life Sciences
BioIntelligent manufacturing is a new derivative of the Industry 4.0 initiative and is of growing interest. From the molecular perspective, the biologicalisation of processes is dependent upon advances in biochemistry, many ‘omics, and synthetic biology in animal, bacterial, and plant-based systems. From another direction, advances in fermentation and cell culture technologies are providing a cell-based biologicalisation of processes. The harmonization of digital manufacturing principals with structures from biological systems is yielding bio-inspired materials and constructs for cell assembly, tissue and organoid engineering. 3D bioprinting supports this by enabling the production of diverse bio-based analytical and diagnostic products, including microfluidic and organ-on-a-chip in vitro tissue models for both new drug development and clinical diagnostics. 3DBP therapeutic products here include bioprinted patches, tissues and even organs. 3DBP (and personalized 3DBP) diagnostic and therapeutic materials, entities, devices and cell therapies all contribute to the elimination of old-fashioned and unsustainable product and manufacturing chemistries, toxic drug therapies, and undesirable animal-based models.
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