Abstract

Biomimetic Microtopographies Trigger New Potential Therapies For Cornea Replacements

Christine McBeth, Research Scientist, Fraunhofer CMI at Boston University

Corneal endothelial cells maintain visual acuity by regulating water content in the cornea. Damage to this region requires corneal transplant from donor tissue. Using 2-photon lithography for molding, a biomimetic membrane triggers pluripotent cells to differentiate into corneal endothelial like cells. This work with Fraunhofer IPT provides foundational understanding of mechanical cues required in this tissue. Our future directions involve scaling this work to translate production to clinical test levels.