Abstract

A Straightforward, Automated and Standardizable Approach to Purifying and Characterizing the Biophysical Properties of EVs; Size, Concentration and Surface Charge

Shayne Harrel, Chief Scientist-Americas, iZON Science Ltd.

The ever increasing discovery of the role of extracellular vesicles (EVs) in a wide range of biological roles and functions has lead them to be realized as a prime candidate for the next generation platform of medical diagnostics and therapeutics.  As such, an accurate, repeatable and standardizable approach to measuring the biophysical properties of these particles such as concentration, particle size and surface charge and correlating these biophysical properties to biological role and function is desperately required.  This presentation will focus on recent developments at Izon Science which have created an integrated methodology for the straightforward, automated purification of EVs and subsequent characterization of their biophysical properties.